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doi: 10.1038/nn1692 251 XuY.OrlandiC.CaoY.YangS.ChoiC

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At the same time, most senescent cells also developed inflammatory secretion of SASP by paracrine effect on neighboring cells or through the endocrine function of the distance, the induced or accelerated age-related disorders ( Fibroblasts obtained from naturally aged skin elevate the synthesis of cysteine-rich protein 61 (CCN1), which impairs the balance of collagen and results in skin dysfunction