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the reaction can only take place if both reactive partners are present

one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)

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