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Serum ARG introduction to endothelial cells via the cationic amino acid y+ transporter 1 depends on both ARG and ADMA levels, since they compete for the transporter [58]

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Besides, the presence of quinone moiety apart from contributing the cytolytic ability by generating the intermediate radicals, which further react with the oxygen and forms superoxide ions and these ions also shows a high tendency towards the damaging the cell membranes causes a dose-dependent the cardiac myopathy [5, 6]
