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With an increase in oxidative stress, Nrf2 is released and translocates to the nucleus, where it binds and activates the ARE and upregulates several genes associated with glutathione synthesis and antioxidant defense (Figure 2) [45,48]

SARS-CoV-2 main protease (Mpro) is a NSP and has been previously identified as a potential target for antiviral drugs designed against SARS-CoV-2 [82]

You should see a small droplet of fluid appear at the needle tip

Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway

and documentation requirements
