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Moreover, it has been recently proven that IGF-1 central administration also induced improvement in insulin sensitivity [291], meaning that this sudden rise after exercise or treatment could be of benefit not only in the periphery, but acting centrally

Given such advances, one could imagine developing metabolomic profiles, backed up with large databases and artificial intelligence, that could be used for point-of-care testing, health screening and diagnosis

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174 One reason for inconsistent results may be the lack of a standardized protocol, including dose of pulses and duration of treatment