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Melatonin supplementation (3 mg/day) has been shown to improve objective and subjective sleep quality, increase 6-sulfatoxymelatonin levels, and enhance total antioxidant capacity in FM patients, suggesting dual chronobiotic and antioxidant benefits (31)

Similarly, in a spinal cord injury model using Sprague-Dawley rats, we observed a notable shift towards an anti-inflammatory cytokine profile at the injury site and in the serum of the transplanted rats, characterized by an increase in IL-10 and TGF-1, alongside a decrease in TNF- and IL-6 post-transplantation

X.SunJ.NitulescuM.et al

In addition, unbiased studies of combinations of treatment options for supplements, including large cohort clinical trials, will lead to evidence-based medicine

[DOI] [PubMed] [Google Scholar] Brock, C

However, pesticide residues in harvested commodities introduce a food-safety dimension