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In summary, GSHee and L-CYSee 21 may represent the first examples of a novel class of thiolester compounds that are able to effectively prevent the ventilatory depressant effects of powerful opioids such as fentanyl (and perhaps other high potency opioids such as sufentanil and alfentanil) and their deleterious effects on breathing stability and gas-exchange within the lungs without compromising the analgesic actions of the opioids

1: Effects on mortality, pathology and sensory-motor performance in aging rats

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Genome-wide association studies and clinical investigations have established a link between the MTHFR C677T polymorphism and a heightened susceptibility to hypertension and hypertension in pregnancy, with a potential increase in risk of up to 87% [98]

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