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Medications know to cause bone marrow suppression (e.g., myelosuppressive antineoplastic agents) may result in a blunted or impeded response to methylcobalamin, vitamin B12 therapy

Writing down any side effects, how bad they are, and how long they last can help your doctor understand your condition better

All protocols require informed consent, medical oversight, and realistic expectations about potential outcomes

Practical Interpretation The mechanistic plausibility (NNMT NAD SIRT1/PGC-1 BMR & fat oxidation) is strong and consistent across preclinical models

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