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Paclitaxel does not directly affect mitochondrial DNA but induces swollen and vacuolated mitochondria in both myelinated and unmyelinated sensory axons, and these changes are accompanied by increased production of reactive oxygen species in the nervous system [20, 53,54,55]

FAMEs were then extracted twice adding 1 ml of hexane, centrifuging 10 min at 2,000 x g and transferring the upper phase to a new glass tube

One proposed mechanism underlying these effects is frequent upward social comparison, whereby individuals evaluate their own appearance against idealized and often unattainable body standards (31, 32)

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