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Chen, J

4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Table 1 and Figure 6, such inhibitors mainly include MvH45 (Van Haren et al., 2017), AK-12 (Ruf et al., 2022), MS2756 ( MS2734 ( GYZ-78 ( NS1 ( LL320 ( CC-410 (Roberti et al., 2023)

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As Kannt & Pfenninger highlight in Frontiers in Physiology , maintaining NAD levels is a cornerstone of metabolic health, supporting mitochondrial function and improving resistance to metabolic stress (Kannt & Pfenninger, Frontiers in Physiology )