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The intestinal transport of molecules from the intestinal lumen to the lamina propria can occur through two distinct mechanisms: paracellular diffusion through tight junctions (TJs) between adjacent intestinal epithelial cells (IECs) and transcellular transport involving endocytosis/exocytosis (transcytosis) mediated or not by membrane receptors

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All clinical context comes from compound-level research

Not every physician is comfortable prescribing these medications or knowledgeable about optimal protocols

When the researchers aspirated and analyzed the participants stomach contents, they found that in meals containing one to six grams of gluten, the enzyme digested an average of at least 97 percent of the gluten by 20 to 35 minutes after drug administration

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