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Carlin CS, Feldman SR, Krueger JG, Menter A, Krueger GG

A., Bozaykut, A., & zdemir, G

A vitamin B-12 supplement of 500 g/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status

The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

The rationale for combining these two peptides is rooted in their complementary mechanisms of action

This route has a few distinct advantages