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When the dose was doubled, the 24-h Uox values for 4 out of 5 subjects reached normalization at one or more postdose time points, and their mean maximal 24-h Uox reduction was 71% (range: 6280%)

Only a few studies have reported the genes regulating important traits in purslane

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These changes disrupted mitochondrial dynamics, leading to structural abnormalities, such as disorganized cristae, and excessive ROS production [187]

Such effect occurs due to everolimus ability to block p53-induced p21 expression (201)

Continuous lipid accumulation impairs mitochondrial function and elevates ROS production, 64 leading to lipid peroxidation, DNA damage, and protein denaturation, collectively initiating oxidative stress, inflammatory signaling, and hepatocellular injury