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To this purpose, ciliotoxicity ex vivo studies on sheep nasal mucosa were conducted, monitoring for ciliary or epithelial damage, necrosis or hemorrhage in response to nanoparticle-mediated drug delivery [77]

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After two weeks, the continuation dose should be increased to 53 mg once daily if the QT interval [116] corrected by Fridericia's formula (QTcF) is less than or equal to 450 ms

We used PyMol software to edit the structure of the key target and AutoDock software to set luteolin as a semi-flexible docking ligand with the key target, perform molecular docking, evaluate the interaction and binding mode, and display the lowest binding energy

J Cell BioI