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A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins

1998 Nov;46(11):939-42

While this is not a side effect in the traditional sense, it's important to be aware that long-term use of high doses for skin-lightening purposes may have unintended consequences and may not be safe

Adverse side effects affect more than 1 out of each 100 vaccinated

Benefits: Visible skin lightening throughout the body