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In controlled studies and research summaries, DSIP has been associated with

This amplifies gut-to-brain signaling and increases the brains sensitivity to gastrointestinal sensations ( The bloodbrain barrier around the area postrema, is more porous thus allowing it to act as a chemosensory trigger zone for nausea and vomiting ( Unfortunately, beyond the specific GLP-1 pathways, multi-agonist therapies do not bypass the gastrointestinal adverse events despite broader receptor targeting

It directly impacts both measured outcomes and dropout rates due to nausea

Moreover, it is one of the main components of the intestinal microbiome, and its amount accounts for a total bacteria above 5% (55)

Delye C, Clement JA, Pernin F, Chauvel B, Le Corre V