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In a study by Cao et al., selenium deficiency severely compromised bone microarchitecture as a result of increased bone resorption 66

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Weight of evidence: Overall evidence is Low, some RCTs document benefits for social communication and internalizing symptoms, but findings are inconsistent across age groups and severity levels, and no study integrates redox biomarkers to confirm mechanistic effects

Participants were given either a glutathione supplement or a placebo before consuming a moderate dose of alcohol

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Lack of change in midazolam half-life (1.07 (0.981.17)) suggested that kratom primarily inhibited intestinal CYP3A