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Combination with Endocrine Therapies Interactions identified between the IGF axis and endocrine pathways provide a mechanistic rationale for investigating IGF-targeted therapies in combination with hormone therapy in breast and prostate cancers [133, 134, 164, 195197]

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it decreases to 70% for the second stage, 58% for stage III, and fewer than 15% for stage IV (128)

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