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doi: 10.1007/s11239-016-1450-4

This is achieved in part through the transcriptional activation of genes such as MMP2 and MMP9, which encode matrix metalloproteinases that degrade extracellular matrix barriers (81), as well as CXCR4, a chemokine receptor important in glioma cell migration along stromal cell-derived factor 1 (SDF-1) gradients

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There is a close relationship between nano materials and bone regeneration, especially in four main aspects: (1) Appropriate components in biomaterials can provide continuous nutrition for bone biomineralization [92]