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For instance, while REW-containing IgG2 is equipped with the capacity to mediate induction of classical complement activation, IgG4 REW remains inert in this regard, which is a differentiator compared to other reported Fc-engineered strategies

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High levels of Zn, Cd, Cu, Fe, and/or Ni can significantly induce the expression of NA synthase genes (responsible for the synthesis of NA by trimerization of S-adenosylmethionine) (reviewed by Hassan and Aarts, 2011

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Historical Background and Scientific Context Scientific interest in DSIP emerged during the twentieth century as researchers sought to better understand naturally occurring peptide messengers and their role in biological signalling systems