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Selenium is required for the production of thyroid hormone-metabolizing enzymes and selenium supplementation is thought to improve the function of thyrocytes and immune cells 4

Notably, in the conversion of GSSH to GSH, several differentially abundant proteins (DAPs) were upregulated in LT-R, including G6PD (glucose-6-phosphate 1-dehydrogenase, G6PD and G6PD6), GS (glutathione synthetase, GSH1 and GSHRP2), and -ECS (-glutamylcyclotransferase, GCT23), whereas downregulated expression of IDH (isocitrate dehydrogenase, ICDH-1 and ICDHP) and GST (glutathione S-transferase, GSTFD, GSTU8-1, GSTU18, GSTU9-1, GSTF, GSTF13, GSTU9, GSTU8, GSTXC, GSTFB, GSTF11, GSTL1, GSTXC-1, MGST3, and UBP25)

Affected the expression of genes related to the vascular system

Wei and Van Griensven, 2008)

Mov Disord 24:13391343 Mller T, Riederer P (2023) The vicious circle between homocysteine, methyl group-donating vitamins and chronic levodopa intake in Parkinsons disease

Discussions The variations observed between ethanol and aqueous extracts in total phenolic content (TPC), total flavonoid content (TFC), and antioxidant assays can be attributed to differences in solvent polarity and the chemical nature of the extracted phytoconstituents