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During aging, the kidneys undergo progressive hypoplasia, along with macro- and microhistological changes, which are exacerbated by systemic comorbidities such as hypertension, diabetes mellitus, and preexisting renal disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] 204.Jimeno A., Wickramasekara S., Maruyama S., Garde N., Heywood M., Bailey C., et al

In vitro studies have shown that tannins and hydrolyzed tannins may cause hepatocyte necrosis