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Description
Toxicity increases as particle size decreases, because small particles are more readily taken up by gastric epithelial cells, leading to oxidative stress and mitochondrial dysfunction [47]

ScottSMvan den BergMMBenningaMA

Maternal high-fat diet during lactation impairs thermogenic function of brown adipose tissue in offspring mice

Not assuming it does but being curious

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Therefore, developing personalized prebiotic/synbiotic formulas based on individual microbiome characteristics is a key direction for improving their efficacy and reliability
