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In the stage of cancer progression, administration of high doses of vitamin C, especially in combination with redox-active metals (copper, iron) may increase the cellular prooxidant state triggering cytotoxicity of cancer cells (Pawlowska et al

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In studies with Sprague Dawley rats, daily intraperitoneal injections of AgNPs at 0.251 mg/kg over 15 or 30 days produced dose- and time-dependent liver damage

doi: 10.1159/000197874

Glutathione is well known for its skin-brightening properties and ability to reduce dullness
