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167 Therefore, there is conflicting evidence regarding the effects of methotrexate on the risk of metabolic syndrome and its individual components (Figure 3)

I have not observed it in clinical practice

In particular, morphological atrophy of astrocytes is prominently presented in neuropsychiatric diseases including mood disorders, post-traumatic stress disorders, addiction, and in some forms of autistic spectrum disorders

4.2.2 LOX inhibitors LOXs drive ferroptosis by catalyzing PUFA oxidation, making them promising therapeutic targets for mitigating ferroptosis-related diseases (Shah et al., 2018)
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