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Hydroxocobalamin offers superior absorption, longer retention, and greater efficacy versus cyanocobalamin and methylcobalamin, making it the preferred choice for severe deficiency and for those needing frequent injections
Also, extracellular ATPs can induce drug resistance
2019 systematic review places this human trial history in context alongside the broader musculoskeletal preclinical literature
doi: 10.1095/biolreprod.113.116186
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