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The authors reported modestly higher objective sleep efficiency and shorter sleep latency in the DSIP arm versus placebo, but subjective sleep-quality measures did not improve and the authors themselves concluded that short-term treatment of chronic insomnia with DSIP is not likely to be of major therapeutic benefit. That is the strongest controlled human sleep study in the literature, and its conclusion is negative to modest

A well-known method of repressing transcription is methylation close to gene promoters

10.1016/j.actbio.2019.09.019 6 AtliO.BaysalM.Aydogan-KilicG.KilicV.UcarcanS.KaradumanB.et al (2017)