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This is because injections bypass the entire digestive system

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In contrast, the current widely employed SARS-CoV-2 vaccines adopt a narrow-spectrum approach they deliver spike (S) glycoproteins that vary antigenically between strains, resulting in immune protection that is predominantly species-specific or even variant-specific [5]
doi: 10.1016/S0006-3223(97)00277-1

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Theoretical concerns exist for individuals with active cancer due to angiogenic properties, though research hasn't identified increased cancer risk