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Description
Severe SARS-CoV-2 infection with high cytokine levels causes T-cell exhaustion characterized by high levels of programmed cell death protein 1 and low numbers of CD4 + and CD8 + cells (Diao et al., 2020
Heliyon 10 , e24573 (2024)
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However, the critical limitation remains the near-total absence of rigorous human clinical trial data
290,291 Additionally, Siegwarts team introduced the fifth component, selective organ targeting, to achieve precise and universal extrahepatic-targeted mRNA delivery strategies
McInerney and J.A
