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A useful way to frame the difference: tretinoin is a top-down instruction that reprograms the epidermis, whereas GHK-Cu is a bottom-up supply of signal and cofactor that helps the dermis rebuild

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Wieman TJ, Smiell JM, Su Y

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doi: 10.1007/s00210-024-03539-0 62 WonCSOberliesNHPaineMF

von der Goltz, C

Additionally, some important cytokines, such as interleukin (IL)-10 and transforming growth factor-beta (TGF-), are expressed at lower levels in maternal-fetal immune tolerance than in pregnant women without HT