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Bridging the gap between experimental success and clinical application requires further research to establish standardized EV-based treatments, ultimately advancing personalized and effective GBM therapies

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clinical studies have yielded conflicting results regarding the relationship between copper ion levels and the development of cardiovascular disease (76)

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In addition, the core molecular oscillator plays a conserved role in regulating the response to oxidative stress 9,10,11 , which increases during aging 12 and contributes to age-related pathologies 13

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