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Description
In case of mutations affecting the function of the bile salt transporter, but especially when the FGF19-driven negative feedback pathway is defective, this leads to bile acid diarrhea type 2 (168)
Nonetheless, I figured Id mention them
Both have a wealth of scientific support for their efficacy, but tirzepatide has a bit more evidence behind it
In terms of mechanism of action, Kojic Acid inhibits tyrosinase activity to prevent melanin formation, while Alpha Arbutin releases hydroquinone slowly to achieve a similar inhibitory effect on melanin synthesis
they specifically target collagen fibers
These damaging compounds can lead to graying hair, as oxidative stress accelerates apoptosis (cell death) of melanocyte stem cells
