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Additionally, alcohol influences oesophageal motility by reducing LES tone, further predisposing individuals to reflux symptoms (Reference Bode and Bode180)

2007 doi: 10.1016/j.abb.2007.12.014

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Germline and somatic mutations in METs kinase domain leading to constitutive activation are seen in renal papillary carcinoma, childhood hepatocellular carcinoma and colorectal cancer [10,11,12], whilst intronic mutations leading to an exon 14 deleted splice variant are seen in non-small cell lung cancer (NSCLC) [6]

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