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Use in Patients With Impaired Hepatic Function: Because buprenorphine levels cannot be rapidly decreased, SUBLOCADE is not recommended for patients with pre-existing moderate to severe hepatic impairment

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In the late 1970s the concept of Roberts cytoprotective homeostasis (cell protection) was related to the stomach, 14 - 19 but soon it was further extended (i.e., as a principle acting in the stomach mucosa integrity maintenance much like in the maintaining of the other epithelia integrity, stomach cytoprotection organoprotection)

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