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The role of GnRH agonists plus add-back therapy in the treatment of endometriosis

We did not observe metabolite-induced aggregate formation in subthreshold PolyQ 19 or GFP only strains (data not shown), indicating that the metabolite alters the ability of threshold-state animals to handle polyQ misfolding

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however, subsequent doses will be titrated to maintain serum -hydroxybutyrate levels between 1.5 and 2.5 mM, with protocolized monitoring of vital signs, serum pH, glucose levels, and adverse gastrointestinal effects [111]

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