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More importantly, POI is fundamentally a chronic disease, and treatment goals should not be limited to short-term improvements in hormone levels but should also focus on the long-term stability of ovarian function and the restoration of reproductive potential

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Statistical analysis The metabolite concentration data were entered into Metaboanalyst 5.0 software for multivariate analyses, including t tests, where BenjaminiHochberg correction was applied with a false discovery rate (FDR) of 0.1 to account for multiple testing

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[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Vojdani A, Vojdani E, Saidara E, Maes M

More specifically, NADPH, generated through the oxidative branch by glucose-6-phosphate dehydrogenase (G6PD), fuels antioxidant systems to prevent ROS-induced DNA damage [78]