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The consequences of impaired methylation pathways are devastating and result in reduced activity of proteins, reduced production of brain neurotransmitters (seretonin, dopamine, GABA etc), increased inflammation, decreased production of glutathione, alterations in DNA and in cell membrane signaling

Here, they get monthly vitamin B12 injections

Genetic toxicology testing (Ames test, chromosomal aberration assays, micronucleus testing) returned negative results

Surprisingly, expression of acyl-CoA:cholesterol acyltransferase 1, the enzyme that mediates the esterification of cholesterol to cellular cholesteryl esters was increased 24-fold in WAT and 58-fold in BAT

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Ask your doctor about a referral to a pain specialist or physiatrist who can build a multi-modal plan with you