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Phosphorylated Flt1 cannot significantly promote the proliferation of endothelial cells, but it can activate the actin reorganization induced by P38-MAPK of the mitogen-activated protein kinase (MAPK) family and promote the migration of endothelial cells (44), while PIGF binds to Flt-1 to increase endothelial cell proliferation by activating p38 MAPK (45)
Stancic-Rokotov D, Balenovic D, Udovicic M, et al
In the case of vitamin B12 deficiency, SAM cannot be formed
