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in contrast to active thioredoxins, it is unable to catalyze the in vitro reduction of insulin by dithiothreitol (Goemans et al., 2018b)

Five positions judged to govern ketosteroid isomerase activity based on mutational studies ( The catalytic efficiency of HsaGST A3-3 with 5-AD is 5000-fold higher than that of HsaGST A2-2, and we found that mutating the five residues in the H-site of HsaGST A2-2 into the corresponding HsaGST A3-3 residues enhanced the efficiency to 70% of the HsaGST A3-3 value (Table 1)

Hi Karine, My daughter whos a nurse also has a lump below clavicle and noticed a couple of days after

Nat Genet 33 : 177182

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(PubMed) Zempleni J, Mock DM