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In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]
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1 2 3 "Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation" (PDF)
