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In this regard, it is important to point out that the two substypes share only 54% overall amino acid homology that mainly comprises the transmembrane/ligand-binding regions (Park and Steinberg, 2018)

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Inflammatory factors directly act on the central nervous system, causing symptoms such as drowsiness, loss of appetite and social withdrawal (21)

10.1016/s1470-2045(12)70490-70494 Lancet Oncol

Indeed, TJs allow the paracellular transport of some medium-sized hydrophilic molecules, ions, or positively charged molecules but prevent the transport of proteins, such as antigenic macromolecules, lipids, and microbial-derived peptides (168)