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10.1016/j.ijpharm.2023.123570 88 GnanapradeepanK.IndegliaA.StiegD
The sum of these events results in NAFLD development (25)
Also, the active substance needs to reach the target site within a certain time, and be available there for a defined time
As well, GSH detoxifies many agents that can induce the mPT in brain mitochondria including 4-hydroxyhexenal (a lipid peroxide) [39]
Here we describe the synthesis and kinetic characterization of a fluoromethyl-M(5) analogue that acts as a mechanism-based inhibitor of both enzymes
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