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Considering that the rate constant of superoxide radical dismutation by SOD1 is 2 10 9 M 1 s 1 and assuming concentrations of SOD1 and vitamin C = 10 M and 5 mM, respectively, vitamin C removes approximately 8% of the cytoplasmic superoxide radical

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In addition, the 21-day AL initiation regimen should be used in patients who are cytochrome P450 (CYP) 2D6 poor metabolizers, in patients taking strong CYP 2D6 and/or CYP 3A4 inhibitors, and in patients taking strong CYP 3A4 inducers, whereas the 1-day AL initiation regimen using AL NCD should be avoided because no dose adjustment is possible for AL NCD

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Cancer 139 , 26712678 (2016)

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