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Furthermore, the mechanisms and behavioral traits of cell death mediated by cystine deletion have been shown to be similar to those in renal cell carcinoma cells with VHL deletion (13)

In contrast, H 2 O 2 present in higher levels may irreversibly oxidize thiolate anions to sulfuric (SO 2 ) or sulfonic (SO 3 ) species, consequently promoting oxidative damage of biomolecules (Schieber and Chandel, 2014)

For example, the cytosolic glutathione pool may well be less oxidized than that measured in extracts because a substantial amount of the GSSG generated by oxidative stress is shipped to the vacuole, possibly by ABCC transporters (Martinoia et al., 1993

doi: 10.1016/j.chemosphere.2023.138038

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