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D., Watkins, L

253 , C171C175 (1987)

The selected studies are summarized in Tables 1 4

The rate-limiting step in the de novo synthesis of the GSH is catalyzed by gamma-glutamyl-cysteine synthetase (also known as glutamine-cysteine ligase), which is a target gene of Nrf2

While environmental triggers (e.g., viral load, infections) play a major role, genetic predisposition often determines who escalates to a full cytokine storm versus those who mount a controlled response

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