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Intratumor metabolic heterogeneity and differential amino acid requirements among tumor cells, microenvironment components, and between between primary and metastatic sites are poorly understood in the context of primary bone tumors and filling these gaps in knowledge should be a priority for investigation in sarcomas

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doi:10.1039/c3an36528j Zhen Z, Tang LJ, Long H, Jiang JH (2012) Enzymatic immuno-assembly of gold nanoparticles for visualized activity screening of histone-modifying enzymes

In cardiomyocytes, ROS activate ERK/p38 MAPK pathways to mediate hypertrophy and induce apoptosis via JNK/p53 pathways and mitochondrial membrane permeability alterations [323, 324]

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