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[56] Brevetti G, Diehm C, Lambert D.J Am Coll Cardiol

In summary, the accumulation of TMAO will not only increase oxidative stress and endothelial cell damage and permeability but also lead to an increase endothelial-derived NOS expression ( Vascular Calcification: TMAO Activates the NLRP3 Inflammasome and NF-B Signaling Pathway in Vascular Smooth Muscle Cells (VSMCs) Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the medial layer of arteries

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found that white meat consumption did not correlate with an increased risk of colorectal cancer, further supporting the idea that it poses fewer health risks than red meat