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In contrast, it has been demonstrated that overexpression of NNMT in mouse liver leads to a decrease in NAD + levels ( in vitro experiments that NNMT promotes the migration and invasive ability of esophageal squamous cell carcinoma (ESCC), and NNMT also promotes the process of epithelial mesenchymal transition (EMT) by affecting the post-transcriptional modification of E-calmodulin

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