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Etiology of MetS Despite decades of investigation, the precise cause of MetS remains unclear

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The authors concluded that due to the high prevalence of MTHFR variants and how crucial it is to assure pregnant women get adequate supplementation, L-methylfolate may be the best option to avoid blood folate deficiencies. The study also notes that excessive ingestion of folic acid could mask an undiagnosed B12 deficiency, and that it was unlikely that methylfolate would mask a B12 deficiency in the same way

It works by neutralizing free radicals unstable molecules that can damage cells if left unchecked

[DOI] [PubMed] [Google Scholar] Bckmann R

The vitamin can be stored in the liver for a long time, so it may take a few years for a deficiency to develop