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Although CPT1A and CPT1B exhibit considerable sequence similarity, the sensitivity of these two enzymes to their physiological inhibitor, malonyl-CoA, differs greatly (CPT1A has a ten-fold higher Ki for malonyl-CoA) 39,40

This diet-microbiome-metabolome axis epitomizes a central hub in human physiology, with profound implications for precision nutrition

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After the discovery of l-carnitine in muscle extracts in 1905 [1] and its structural identification in 1927 [2], the importance of l-carnitine in fatty acid oxidation in the liver and the heart was first described by Fritz in 1959 [3]

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